This research aimed to 1) study human resource management and operational efficiency during the pandemic crisis 2) compare operational efficiency according to demographical factors, and 3) study the relationship between human resource management and operational efficiency of city hall personnel. The sample group was city hall 256 employees in northeastern region of Thailand. Research instrument was questionnaire, statistics used for analysis were descriptive statistics and inferential statistics using independentsamples t-test, One-Way Anova and multiple regression with statistics SPSS application. Research showed personnel variables had the highest level in human resource management with mean score at 4.44. On recruitment, hiring selection process compensation and benefit, operational evaluation, and training and development had mean score at 4.48, 4.46, 4.45, 4.42, and 4.38 respectively. Personnel variables had the highest level in operational efficiency with mean score at 4.43. Volume of work, expense, quality of work, and operational time had mean score at 4.48, 4.42, 4.41, and 4.41 respectively. Personnel with different gender and monthly income had different perspective on operational efficiency with statistically significance 0.05. Human resource management had influence on operational efficiency could predict operational efficiency at 64.2 percent with constant value of predication equation at 0.805 with statistically significance 0.05.